Potassium Bromide → HCID 18368083, compound

HRID 379761Notes

Reaction equation

[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:14])=[CH:11][CH:12]=2)[N:7](C(OCC)=O)[C:6]=1[C:20]([C:22]1[S:23][CH:24]=[CH:25][CH:26]=1)=[O:21])(=[O:3])[CH3:2].[K+].[Br-]>>[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:14])=[CH:11][CH:12]=2)[NH:7][C:6]=1[C:20]([C:22]1[S:23][CH:24]=[CH:25][CH:26]=1)=[O:21])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 18367807HCID 18367807, compound

Product 1

HCID 18368083HCID 18368083, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 2 (Method A) from 3-acetylamino-6-chloro-1-(ethoxycarbonyl)-2-(thiophene-2-carbonyl)indole (step2). m.p.: 228-231° C. 1H-NMR (CDCl3) δ: 10.10 (1H, br s), 8.40 (1H, br s), 8.25 (1H, d, J=9.2 Hz), 7.86 (1H, dd, J=1.1, 3.7 Hz), 7.77 (1H, dd, J=1.1, 5.1 Hz), 7.34 (1H, d, J=1.8 Hz), 7.27 (1H, dd, 3.7, 5.1 Hz), 7.12 (1H, dd, J=1.8, 8.8 Hz), 2.29 (3H, m) IR (KBr) ν: 1660, 1560, 1440, 1325, 1250 cm−1

Sources & evidence

ORD record: ord-5bb15c5c454844cfa53d122887909be2
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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