Acetyl chloride → HCID 18368220, compound

HRID 379777Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14].[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:17])[C:13]([CH3:14])([CH3:16])[CH3:15])(=[O:20])[CH3:19]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 18367800HCID 18367800, compound

Product 1

HCID 18368220HCID 18368220, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-trimethylacetylindole (Example 89) and acetyl chloride. m.p.: 190-193° C. 1H-NMR (CDCl3) δ: 10.46 (1H, br s), 8.40 (1H, br s), 8.22 (1H, d, J=9.2 Hz), 7.29 (1H, s), 7.05 (1H, d, J=9.2 Hz), 2.29 (3H, s), 1.42 (9H, s)

Sources & evidence

ORD record: ord-94305ede676844d9be4b11361d0b877d
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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