Ethyl Acetate → 3-Acetylamino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole

HRID 379781Notes

Reaction equation

HRID 379781 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:3]=1[C:17]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)=[O:18].[C:29](OCC)(=[O:31])[CH3:30]>>[C:29]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:3]=1[C:17]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)=[O:18])(=[O:31])[CH3:30]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 183680233-Amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole

Product 1

HCID 183677563-Acetylamino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 2 (Method A) from 3-amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole (step 1). tlc: Rf =0.6 (50% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-2dbad3c5a0b04aa1ba7e027f248eca13
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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