Ethyl Acetate → 2-(Ethoxycarbonylamino)-5-nitrobenzonitrile

HRID 379782Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[C:13]([O:16][CH2:17][CH3:18])(=[O:15])C>>[CH2:17]([O:16][C:13]([NH:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5])=[O:15])[CH3:18]

Participants

Reactant 2

HCID 8857Ethyl Acetate

HCID 285322-Amino-5-nitrobenzonitrile

Product 1

HCID 183679462-(Ethoxycarbonylamino)-5-nitrobenzonitrile

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 (Method A) from 2-amino-5-nitrobenzonitrile. tlc: Rf=0.4 (33% ethyl acetate in hexanes)

Sources & evidence

ORD record: ord-8f6ee95eee25480098e951d950f26b0a
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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