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HRID379798

反应详情

EQUATION

反应方程式

HRID 379798 的结构方程式

REACTANTS

反应物

2
结构：CCC(=O)Cl
HCID62324

Propanoyl chloride

C3H5ClO

结构：CCOC(=O)n1c(C(=O)c2cccc(Cl)c2)c(N)c2cc(Cl)ccc21
HCID18367741

未命名化合物

PRODUCTS

生成物

1
结构：CCC(=O)Nc1c(C(=O)c2cccc(Cl)c2)[nH]c2ccc(Cl)cc12
HCID18367763

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 2 (Method A) from 3-amino-5-chloro-2-(3-chlorobenzoyl)-1-(ethoxycarbonyl)indole (step 1) and propionyl chloride. m.p.: 206.5-207.5° C. (ethyl acetate) 1H-NMR (CDCl3) δ: 9.78 (1H, br s), 8.31 (1H, s), 8.28 (1H, br s), 7.78 (1H, s), 7.70-7.59 (2H, m), 7.51 (1H, t, J=8 Hz), 7.34 (1H, dd, J=8, 1.5 Hz), 7.25 (1H, d, J=8 Hz), 2.51 (2H, q, J=7 Hz), 1.30 (3H, t, J=7 Hz)