HCID 18367790, compound → HCID 18368037, compound

HRID 379810Notes

Reaction equation

HRID 379810 reaction equation
[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:15])=[C:11]([Br:14])[CH:12]=2)[N:7](C(OCC)=O)[C:6]=1[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[N:24]=1)=[O:22])(=[O:3])[CH3:2]>ClCCl.CO>[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:15])=[C:11]([Br:14])[CH:12]=2)[NH:7][C:6]=1[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:29])[N:24]=1)=[O:22])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 18367790HCID 18367790, compound

Product 1

HCID 18368037HCID 18368037, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 2 (Method A) from 3-acetylamino-5-bromo-6-chloro-1-(ethoxycarbonyl)-2-(6-methylpyridine-2-carbonyl)indole (step 2). m.p.: 234-236° C. (dichloromethane/methanol) 1H-NMR (DMSO-d6) δ: 12.01 (1H, br s), 10.26 (1H, br s), 8.21 (1H, s), 7.98 (1H, t, J=7.7 Hz), 7.86 (1H, d, J=7.7 Hz), 7.85 (1H, s), 7.57 (1H, d, J=7.7 Hz), 2.66 (3H, s), 1.99 (3H, s).

Sources & evidence

ORD record
ord-3181b67c5a0f42d1bf15c062eb87f522
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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