3,3,3-Trifluoropropionic acid → HCID 18367749, compound

HRID 379813Notes

Reaction equation

HRID 379813 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[F:20][C:21]([F:27])([F:26])[CH2:22][C:23](O)=[O:24]>C(OCC)(=O)C.CCCCCC>[C:12]([C:3]1[NH:4][C:5]2[C:10]([C:2]=1[NH:1][C:23](=[O:24])[CH2:22][C:21]([F:27])([F:26])[F:20])=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=2)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 27779723,3,3-Trifluoropropionic acidHCID 183679723-Amino-2-benzoyl-6-chloroindole

Product 1

HCID 18367749HCID 18367749, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared according to the procedure described in Example 114 employing 3-amino-2-benzoyl-6-chloroindole (Example 1) and 3,3,3-trifluoropropionic acid. m.p.: 201-204° C. (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-dfc18caebbb94fb6925d35375db1dff5
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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