Acetyl chloride → HCID 18368038, compound

HRID 379831Notes

Reaction equation

HRID 379831 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:22])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([OH:21])=[O:20])[CH:14]=1.[C:23](Cl)(=[O:25])[CH3:24]>C(OCC)(=O)C>[C:23]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:22])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([OH:21])=[O:20])[CH:14]=1)(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 18368010HCID 18368010, compound

Product 1

HCID 18368038HCID 18368038, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-2-(3-carboxybenzoyl)-6-chloroindole (Example 131) and acetyl chloride. m.p.: >290° C. (ethyl acetate) 1H-NMR (DMSO-d6) δ: 11.85 (1H, s), 9.90 (1H, s), 8.39 (1H, br s), 8.20 (1H, d, J=7.7 Hz), 7.77 (1H, d, J=7.7 Hz), 7.65 (1H, d, J=8.8 Hz), 7.54-7.43 (2H, m), 7.09 (1H, dd, J=1.8, 8.4 Hz), 1.67 (3H, s)

Sources & evidence

ORD record
ord-6eadb581892b4b7bbc3670f847fd64dc
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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