HCID 18367942, compound → HCID 18368035, compound

HRID 379837Notes

Reaction equation

HRID 379837 reaction equation
[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:14])=[CH:11][CH:12]=2)[NH:7][C:6]=1[C:15](=[O:23])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1)(=[O:3])[CH3:2]>Cl.CO>[ClH:14].[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:14])=[CH:11][CH:12]=2)[NH:7][C:6]=1[C:15](=[O:23])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([NH2:22])[CH:17]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 18367942HCID 18367942, compound

Product 1

HCID 18368035HCID 18368035, compoundYield 135.2%

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

3-Acetylamino-2-(3-aminobenzoyl)-6-chloroindole (Example 135, 0.41 g, 1.3 mmol) was stirred in 10% HCl—MeOH (3.0 ml) for 10 min and then solvent removed by evaporation. The residual solid was recrystallized from ethanol/diethyl ether to afford 320 mg (70%) of the title compound as a yellow solid. m.p.:>300° C.

Workup

  1. customsolvent removed by evaporation
  2. customThe residual solid was recrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-c5dc8ea541ae40ce8bc0782892008d5c
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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