Methyl bromoacetate → 3-(N-Acetyl-N-methoxycarbonylmethylamino)-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole

HRID 379852Notes

Reaction equation

[C:1]([NH:4][C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:14])=[CH:11][CH:12]=2)[N:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:6]=1[C:20](=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(=[O:3])[CH3:2].Br[CH2:29][C:30]([O:32][CH3:33])=[O:31]>>[C:1]([N:4]([C:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:14])=[CH:11][CH:12]=2)[N:7]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:6]=1[C:20](=[O:27])[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH2:29][C:30]([O:32][CH3:33])=[O:31])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 183680413-Acetylamino-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole

Product 1

HCID 183681583-(N-Acetyl-N-methoxycarbonylmethylamino)-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole

Procedure

The title compound was prepared according to the procedure described in Example 146 from 3-acetylamino-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole (Example 2, step 2) and methyl bromoacetate.

Sources & evidence

ORD record: ord-cae24f1856d84b388ef6893563876702
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06300363B1

Reaction notes

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