3-(N-Acetyl-N-methoxycarbonylmethylamino)-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole → 3-(N-Acetyl-N-carboxymethylamino)-2-benzoyl-6-chloroindole

Participants

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 2 (Method A) from 3-(N-acetyl-N-methoxycarbonylmethylamino)-2-benzoyl-6-chloro-1-(ethoxycarbonyl)indole (step 1). m.p.: 148-154° C. (dichloromethane) 1H-NMR (DMSO-d6) δ: 12.53 (1H, br s), 12.17 (1H, br s), 7.85 (1H, d, J=8.8 Hz), 7.78-7.62 (3H, m), 7.62-7.51 (3H, m), 7.22 (1H, dd, J=1.8, 8.8 Hz), 3.96 (1H, d, J=17.2 Hz), 3.66 (1H, d, J=17.2 Hz), 1.80 (s, 3H)

Provenance & Evidence