HRID37995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57577780

未命名化合物

结构：CC(C)(C)OC(=O)NC1=Nc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C=C(C(=O)O)C1

HCID66960164

未命名化合物

PRODUCTS

生成物

结构：CCCN(CC(O)CO)C(=O)C1=Cc2ccc(-c3ccc(C(=O)N4CCCC4)cc3)cc2N=C(N)C1

HCID51033629

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by the procedures as described in Example 101 (Step H and I) using (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid and N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)propan-1-amine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d8f8b7754984a908a0d1df78fe26999
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08524702B2
来源说明: uspto-grants-2013_09

反应 SMILES

C(OC([NH:8][C:9]1[CH2:10][C:11]([C:33](O)=[O:34])=[CH:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[O:27])=[CH:22][CH:21]=3)=[CH:16][C:14]=2[N:15]=1)=O)(C)(C)C.CC1(C)[O:41][CH:40]([CH2:42][NH:43][CH2:44][CH2:45][CH3:46])[CH2:39][O:38]1>>[NH2:8][C:9]1[CH2:10][C:11]([C:33]([N:43]([CH2:42][CH:40]([OH:41])[CH2:39][OH:38])[CH2:44][CH2:45][CH3:46])=[O:34])=[CH:12][C:13]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][C:23]([C:26]([N:28]4[CH2:29][CH2:30][CH2:31][CH2:32]4)=[O:27])=[CH:24][CH:25]=3)=[CH:16][C:14]=2[N:15]=1