HRID37997

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)[Si](C)(C)O[C@@H]1CNC[C@H]1O[Si](C)(C)C(C)(C)C

HCID24727995

未命名化合物

结构：CC(C)(C)OC(=O)NC1=Nc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C=C(C(=O)O)C1

HCID66960164

未命名化合物

PRODUCTS

生成物

结构：NC1=Nc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2C=C(C(=O)N2C[C@@H](O)[C@H](O)C2)C1

HCID58267264

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by the procedures as described in Example 101 (Steps H and I) with conc. HCl instead of TFA using (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid and (3R,4R)-3,4-bis(tert-butyldimethylsilyloxy)pyrrolidin.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e697edadcf7f4e1a9a543a6568385c47
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08524702B2
来源说明: uspto-grants-2013_09

反应 SMILES

Cl.C(OC([NH:9][C:10]1[CH2:11][C:12]([C:34](O)=[O:35])=[CH:13][C:14]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[O:28])=[CH:23][CH:22]=3)=[CH:17][C:15]=2[N:16]=1)=O)(C)(C)C.[Si]([O:44][C@H:45]1[C@H:49]([O:50][Si](C(C)(C)C)(C)C)[CH2:48][NH:47][CH2:46]1)(C(C)(C)C)(C)C>>[NH2:9][C:10]1[CH2:11][C:12]([C:34]([N:47]2[CH2:48][C@@H:49]([OH:50])[C@H:45]([OH:44])[CH2:46]2)=[O:35])=[CH:13][C:14]2[CH:20]=[CH:19][C:18]([C:21]3[CH:22]=[CH:23][C:24]([C:27]([N:29]4[CH2:30][CH2:31][CH2:32][CH2:33]4)=[O:28])=[CH:25][CH:26]=3)=[CH:17][C:15]=2[N:16]=1