Water → (Z)-4-(3-carboxyacrylamido)benzoic acid

HRID 380057ノート

反応式

HRID 380057 の反応式
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH:3]=[CH:2]1.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=1.O>CN(C)C=O>[C:13]([C:12]1[CH:16]=[CH:17][C:9]([NH:8][C:4](=[O:5])/[CH:3]=[CH:2]\[C:1]([OH:6])=[O:7])=[CH:10][CH:11]=1)([OH:15])=[O:14]

参加物

5

反応物 3

HCID 962WaterHCID 9784-Aminobenzoic AcidHCID 7923Maleic Anhydride

生成物 1

HCID 5717537(Z)-4-(3-carboxyacrylamido)benzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

One molar equivalent of maleic anhydride and p-amino benzoic acid are dissolved in N,N-dimethylformamide (DMF), and the mixture stirred at room temperature for five hours under nitrogen atmosphere. The resulting solution is poured into a sufficient water to precipitate crude N-(4-carboxyphenyl)maleamic acid. This is filtered, dried, and recrystallized three times from water to obtain pure N-(4-carboxyphenyl)maleamic acid.

後処理

  1. customto precipitate crude N-(4-carboxyphenyl)maleamic acid
  2. filtrationThis is filtered
  3. customdried
  4. customrecrystallized three times from water

出典と根拠

ORDレコード
ord-9d7f61027e1640e5bebdbc2f92cf31d3
出典データセット
uspto-grants-2001_10
特許番号
US06300456B1

反応ノート

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