Trifluoromethanesulfonic acid → HCID 20693366, compound

Participants

Reaction Steps

Under an atmosphere of argon and at −78° C., to a solution of the compound prepared in Example 1(2) (1.50 g) in dichioromethane (10 ml), pyridine (1.1 3 ml) and anhydrous trifluoromethanesulfonic acid (1.13 ml) were added dropwise. The mixture solution was stirred for 2 hours at room temperature. A saturated aqueous solution of sodium bicarbonate (20 ml) was added to the reaction mixture and it was vigorously stirred for 1 hour at room temperature. The reaction mixture was extracted with ethyl acetate. The extract was washed with 1N hydrochloric acid, a saturated aqueous solution of sodium bicarbonate, a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography (hexane:ethyl acetate=19: 1) to give the title compound (2.05 g) having the following physical data.

Provenance & Evidence