(2R)-1-benzyloxycarbonyl-2-(4,5-diphenyloxazol-2-yl)pyrrolidine → (2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidine

HRID 380112노트

반응식

HRID 380112 반응식
C(OC([N:11]1[CH2:15][CH2:14][CH2:13][C@@H:12]1[C:16]1[O:17][C:18]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:20]=1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[C:21]1([C:19]2[N:20]=[C:16]([C@H:12]3[CH2:13][CH2:14][CH2:15][NH:11]3)[O:17][C:18]=2[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

4

반응물 1

HCID 54511676(2R)-1-benzyloxycarbonyl-2-(4,5-diphenyloxazol-2-yl)pyrrolidine

생성물 1

HCID 15505347(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of (2R)-1-benzyloxycarbonyl-2-(4,5-diphenyloxazol-2-yl)pyrrolidine (4 g) and 10% Pd/C (0.5 g) in ethanol (120 ml) was stirred under H2 for 10 hours. The catalyst was filtered off and filtrate was evaporated in vacuo to give (2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidine.

후처리

  1. filtrationThe catalyst was filtered off
  2. customfiltrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-37e8f712b77144a8a1a95c27c1ae8b24
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06300344B1

반응 노트

불러오는 중…