Water → 7-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

HRID 380239Notes

Reaction equation

HRID 380239 reaction equation
[OH2:1].[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8](Cl)=[O:9]>O1CCOCC1>[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8]([OH:1])=[O:9]

Participants

4

Reactant 2

HCID 962WaterHCID 2757681HCID 2757681, compound

Product 1

HCID 183643997-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to ambient temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure, allowing the expecting product to be isolated.

Workup

  1. temperatureAfter 20 hours' reflux
  2. customreturn to ambient temperature
  3. filtrationAfter filtration
  4. washrinsing with water until neutral, the precipitate
  5. dry with materialis dried over P2O5 under reduced pressure
  6. customto be isolated

Sources & evidence

ORD record
ord-7f547cf8cb824ce4b1eb138bd2bd2e6d
Source dataset
uspto-grants-2001_10
Patent number
US06302837B1

Reaction notes

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