Water → 7-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

Participants

Reaction Steps

40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to ambient temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure, allowing the expecting product to be isolated.

Provenance & Evidence