反应详情

A solution of 2-nitro-benzoyl chloride (2.04 g, 90% purity, 10 mmol) in CH2Cl2 (20 mL) was added dropwise into a mixture of 7-fluoro-6-amino-2H-1,4-benzoxazin-3-(4H)-one (1.78 g, 10 mmol) and triethylamine (1.1 g, 11 mmol) in CH2Cl2 (20 mL) over 10 min with ice-water bath cooling. The reaction mixture was then stirred at room temperature overnight. The mixture was poured into water and the resulting precipitate was collected by suction-filtration and washed with hexane and then water to give 7-fluoro-6-(2-nitrobenzoyl)amino-2H-1,4-benzoxazin-3-(4H)-one, 2.9 g (yield: 92%) as a solid: mp >248° C.

1. temperaturecooling
2. filtrationthe resulting precipitate was collected by suction-filtration
3. washwashed with hexane