Methylamine → HCID 15462362, compound

Participants

Reaction Steps

3,5-diiodo-4-(4′-methoxyphenoxy)-N-methyl benzamide (Compound 8) was prepared by way of 3,5-diiodo-4-(4′-methoxyphenoxy)benzoyl chloride (see, Example 1.5). The acid chloride was reacted with excess methylamine in tetrahydrofuran at ambient temperature (1 hour), filtered to remove methylamine-hydrochloride precipitate, the solvent 5 evaporated and the product crystallized from 95% ethanol.

Provenance & Evidence