Methylamine → HCID 15462362, compound

HRID 380454Notes

Reaction equation

HRID 380454 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:20])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:5](Cl)=[O:6].[CH3:21][NH2:22]>O1CCCC1>[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:20])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)[C:5]([NH:22][CH3:21])=[O:6]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 18349331HCID 18349331, compound

Product 1

HCID 15462362HCID 15462362, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3,5-diiodo-4-(4′-methoxyphenoxy)-N-methyl benzamide (Compound 8) was prepared by way of 3,5-diiodo-4-(4′-methoxyphenoxy)benzoyl chloride (see, Example 1.5). The acid chloride was reacted with excess methylamine in tetrahydrofuran at ambient temperature (1 hour), filtered to remove methylamine-hydrochloride precipitate, the solvent 5 evaporated and the product crystallized from 95% ethanol.

Workup

  1. filtrationfiltered
  2. customto remove methylamine-hydrochloride precipitate
  3. customthe solvent 5 evaporated
  4. customthe product crystallized from 95% ethanol

Sources & evidence

ORD record
ord-be1845ce4db6456dba519d92533e81be
Source dataset
uspto-grants-2001_10
Patent number
US06303621B1

Reaction notes

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