Triethylamine → 2,4-Dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Ethanamine, 2,2,2-trifluoro-	HCID 9773	—
Reactant	2,4-Dichloropyrimidine-5-carbonyl chloride	HCID 13784112	—
Solvent	Dichloromethane	HCID 6344	—
Product	2,4-Dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide	HCID 86664758	60%

Reaction Conditions

Temperature	25 °C

Reaction Steps

2,4-Dichloropyrimidine-5-carbonyl chloride (1 g, 5 mmol) was dissolved in CH2Cl2 (20 mL), 2,2,2-trifluoroethylamine (515 mg, 5 mmol) and triethylamine (1.31 mL, 9 mmol) were added. The reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was purified by flash chromatography to yield a white solid (780 mg, 60%). MS: m/z=271.9 [M−H]−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08524710B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-e3e74a819e39477187627512570c9e67
Source note	uspto-grants-2013_09