HRID380481

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12440702

4-[4-(Trifluoromethyl)phenyl]piperidine

C12H14F3N

结构：O=CC1CN(C(=O)c2cccc3ccccc23)CC1c1ccsc1

HCID20694383

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cccc2ccccc12)N1CC(CN2CCC(c3ccc(C(F)(F)F)cc3)CC2)C(c2ccsc2)C1

HCID18364867

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 1-(1-naphthoyl)-3-(SR)-formyl-4-(RS)-(3-thienyl)pyrrolidine (Example 82 and 4-(4-trifluoromethylphenyl)piperidine according to procedures described in Example 1, Step F. 1H NMR (CDCl3) δ7.34 (d, 2H, J=8 Hz), 7.58 (d, 2H, J=8 Hz); Mass Spectrum (CI) m/e=549 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d6fd40df64aa41aea31b15eb5e80a7ce
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06303593B1
来源说明: uspto-grants-2001_10

反应 SMILES

[C:1]1([C:11]([N:13]2[CH2:17][CH:16]([C:18]3[CH:22]=[CH:21][S:20][CH:19]=3)[CH:15]([CH:23]=O)[CH2:14]2)=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[F:25][C:26]([F:40])([F:39])[C:27]1[CH:32]=[CH:31][C:30]([CH:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[CH:29][CH:28]=1>>[C:1]1([C:11]([N:13]2[CH2:17][CH:16]([C:18]3[CH:22]=[CH:21][S:20][CH:19]=3)[CH:15]([CH2:23][N:36]3[CH2:35][CH2:34][CH:33]([C:30]4[CH:29]=[CH:28][C:27]([C:26]([F:25])([F:39])[F:40])=[CH:32][CH:31]=4)[CH2:38][CH2:37]3)[CH2:14]2)=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1