4-(4-(Trifluoromethyl)phenyl)piperidine → 1-(1-Naphthoyl)-3-(RS)-(4-(4-trifluoromethylphenyl)piperidinylmethyl)-4-(RS)-(3-thienyl)pyrrolidine

Participants

Role	Name	HCID	Charge
Reactant	4-(4-(Trifluoromethyl)phenyl)piperidine	HCID 12440702	—
Reactant	1-(1-Naphthoyl)-3-(SR)-formyl-4-(RS)-thiophen-3-ylpyrrolidine	HCID 20694383	—
Product	1-(1-Naphthoyl)-3-(RS)-(4-(4-trifluoromethylphenyl)piperidinylmethyl)-4-(RS)-(3-thienyl)pyrrolidine	HCID 18364867	—

Reaction Steps

The title compound was prepared from 1-(1-naphthoyl)-3-(SR)-formyl-4-(RS)-(3-thienyl)pyrrolidine (Example 82 and 4-(4-trifluoromethylphenyl)piperidine according to procedures described in Example 1, Step F. 1H NMR (CDCl3) δ7.34 (d, 2H, J=8 Hz), 7.58 (d, 2H, J=8 Hz); Mass Spectrum (CI) m/e=549 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06303593B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-d6fd40df64aa41aea31b15eb5e80a7ce
Source note	uspto-grants-2001_10