Triethylamine → HCID 178418518, compound

HRID 3805Notes

Reaction equation

HRID 3805 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[C:11]=[O:12])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[ClH:13].Cl.[Cl:15][C:16]1[CH:32]=[CH:31][C:19]([CH2:20][N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][CH2:29][SH:30])[CH2:23][CH2:22]2)=[CH:18][CH:17]=1.C(N(CC)CC)C>C(Cl)Cl>[OH2:3].[ClH:15].[ClH:13].[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[SH:30][CH2:29][CH2:28][CH2:27][N:24]2[CH2:25][CH2:26][N:21]([CH2:20][C:19]3[CH:18]=[CH:17][C:16]([Cl:15])=[CH:32][CH:31]=3)[CH2:22][CH2:23]2)[OH:12])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 994524-Acetylphenyl isocyanateHCID 137311183-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

Product 1

HCID 178418518HCID 178418518, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure described in Example 2 was followed, using 1.0 g of 4-acetylphenyl isocyanate, 2.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 0.7 g of triethylamine and 50 ml of methylene chloride, to give 0.83 g (29% of theory) of N-(4-acetylphenyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride monohydrate as a white crystalline solid, M.p. 235°-237° C.

Sources & evidence

ORD record
ord-cc89c78e3c7641519d60f0df07730851
Source dataset
uspto-grants-1988_02
Patent number
US04722926

Reaction notes

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