反应详情

A solution of 0.31 g (1.22 mmol) of 7-Carbomethoxy dihydrobenzofuran and 1.66 g (3.3 mmol) of DDQ in 25 mL of toluene was heated at reflux for 7 h. The reaction mixture was then cooled to rt, diluted with ether, and washed with 3×30 mL of sat'd NaHCO3 solution. The organic fraction was dried over MgSO4, filtered and the filtrate was concentrated. The residue was purified by chromatography (silica, hexanes: ethyl acetate, 9:1) to give 0.25 g of the title compound.

1. temperatureat reflux for 7 h
2. washwashed with 3×30 mL of sat'd NaHCO3 solution
3. dry with materialThe organic fraction was dried over MgSO4
4. filtrationfiltered
5. concentrationthe filtrate was concentrated
6. customThe residue was purified by chromatography (silica, hexanes: ethyl acetate, 9:1)