Potassium Carbonate → Benzofuran-7-Carboxylic Acid

HRID 380509Notes

Reaction equation

HRID 380509 reaction equation
[C:1]([C:5]1[C:13]2[O:12][CH:11]=[CH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)([O:3]C)=[O:2].C([O-])([O-])=O.[K+].[K+]>CO>[O:12]1[C:13]2[C:5]([C:1]([OH:3])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=2[CH:10]=[CH:11]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 14229730Methyl benzofuran-7-carboxylate

Product 1

HCID 13307983Benzofuran-7-Carboxylic AcidYield 93.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 0.25 g (0.99 mmol) of 7-Carbomethoxybenzofuran and 0.1 mL of K2CO3 (1N in water) in 6 mL of methanol was stirred at it for 24 h. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by chromatography (silica, hexanes: ethyl acetate, 4:1, then ethyl acetate: methanol, 9:1) to give 0.15 g of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by chromatography (silica, hexanes

Sources & evidence

ORD record
ord-7f078a8f0ebc43c99f74bb5b3def9a81
Source dataset
uspto-grants-2001_10
Patent number
US06303593B1

Reaction notes

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