Formic Acid → HCID 18364916, compound

HRID 380513Notes

Reaction equation

HRID 380513 reaction equation
C([O:8][C:9](=[O:23])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)C1C=CC=CC=1.C(O)=O>CO.[Pd]>[CH3:16][C:12]1[C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:10]([CH:15]=[CH:14][CH:13]=1)[C:9]([OH:23])=[O:8]

Participants

5

Reactant 2

HCID 284Formic AcidHCID 18364851HCID 18364851, compound

Product 1

HCID 18364916HCID 18364916, compoundYield 99.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 0.35 g (1.18 mmol) of benzyl-3-methyl-2-phenylbenzoate and 0.25 g of 10% Pd/C in 8 mL of a 4.4% solution of HCO2H in methanol was heated at reflux for 2 h. The reaction mixture was filtered through a thin layer of celite and concentrated to give 0.25 g of the title compound as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 h
  3. filtrationThe reaction mixture was filtered through a thin layer of celite and
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-d9dd16dc50ba4dbf988cf6cfffa82204
Source dataset
uspto-grants-2001_10
Patent number
US06303593B1

Reaction notes

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