反应详情

To a solution of 4.5 g of 1-N-Benzyl-4-phenyl-4-cyanopiperidine (16.3 mmol, Fisher Scientific) in 50 mL of THF was added 49 mL of lithium aluminum hydride (1 M in THF, 49 mmol) and the reaction mixture was stirred for 12 hr at rt. The reaction was quenched by the addition of 5 mL of water, 5 mL of 15% solution of NaOH followed by 5 mL of water. The organic fraction was dried over MgSO4, filtered and the filtrate was concentrated to give the title compound which was used without further purification.

1. customThe reaction was quenched by the addition of 5 mL of water, 5 mL of 15% solution of NaOH
2. dry with materialThe organic fraction was dried over MgSO4
3. filtrationfiltered
4. concentrationthe filtrate was concentrated