Hydrochloric Acid → HCID 10269463, compound

HRID 380625Notes

Reaction equation

HRID 380625 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([OH:10])=O.[CH:11]([N:13]1[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:14]1)=[O:12].[ClH:25].[NH4+].[Cl-]>>[ClH:25].[CH:11]([N:13]1[CH2:18][CH2:17][N:16]([C:8](=[O:10])[CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:15]([CH2:19][N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:14]1)=[O:12]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 853182-Pyridineacetic acidHCID 22707180HCID 22707180, compound

Product 1

HCID 10269463HCID 10269463, compound

Procedure

The compound was prepared by coupling of 2-pyridinylacetic acid with 4-formyl-2-(R,S)-[(1-pyrrolidinyl)methyl]piperazine; mp: (HCl salt) 125-128° C.; 1H NMR (free base, 200 MHz, CDCl3) δ 1.5-1.7 (4H, m), 2.1-3.6 (10H, m), 3.7-4.9 (5H, m), 6.9-7.3 (2H, m), 7.6 (1H, m), 8.0 (1H, m), 8.6 (1H, m); MS (FAB) 317 (M+H)+; Anal. Calcd. for C17H24N4O2.2HCl.NH4Cl: C, 46.11; H, 6.83; N, 15.82. Found: C, 46.37; H, 6.51; N, 16.35.

Sources & evidence

ORD record
ord-278bb64a7e454f74bae29cae16dad314
Source dataset
uspto-grants-2001_10
Patent number
US06303611B1

Reaction notes

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