Sodium Hydroxide → HCID 69971794, compound

HRID 380644Notes

Reaction equation

HRID 380644 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[C:9]([O:11][CH2:12][C@@:13]2([OH:30])[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[O:23][CH2:24][C:25]([O:27]CC)=[O:26])[CH2:14]2)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+:39]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([C:31]2[CH:32]=[CH:33][C:34]([F:37])=[CH:35][CH:36]=2)[C:9]([O:11][CH2:12][C@@:13]2([OH:30])[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[O:23][CH2:24][C:25]([O-:27])=[O:26])[CH2:14]2)=[O:10])=[CH:4][CH:3]=1.[Na+:39]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11027636HCID 11027636, compound

Product 1

HCID 69971794HCID 69971794, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (0.155 g) and 1N-NaOH (0.286 ml) in MeOH (1.5 ml) was stirred for 16 hours at room temperature. After evaporating in vacuo, the residue was crystallized from ether to give sodium {{(2R)-2-{[N,N-di(4-fluorophenyl)carbamoyloxy]methyl}-2-hydroxy-1,2,3,4-tetrahydro-5-naphthyl}oxy}acetate (sodium salt of (2R)-5-(carboxymethoxy)-2-{[N,N-di(4-fluorophenyl)carbamoyloxy]methyl}-2-hydroxy-1,2,3,4-tetrahydronaphthalene) (111 mg) as white solid.

Workup

  1. customAfter evaporating in vacuo
  2. customthe residue was crystallized from ether

Sources & evidence

ORD record
ord-2ca6ce38a4a14e6aad760f74ae1ee88e
Source dataset
uspto-grants-2001_10
Patent number
US06303649B1

Reaction notes

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