Sodium Hydroxide → HCID 69971794, compound

Participants

Reaction Steps

A solution of (2R)-2-{[N,N-di(4-fluorophenyl)-carbamoyloxy]methyl}-5-[(ethoxycarbonyl)methoxy]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (0.155 g) and 1N-NaOH (0.286 ml) in MeOH (1.5 ml) was stirred for 16 hours at room temperature. After evaporating in vacuo, the residue was crystallized from ether to give sodium {{(2R)-2-{[N,N-di(4-fluorophenyl)carbamoyloxy]methyl}-2-hydroxy-1,2,3,4-tetrahydro-5-naphthyl}oxy}acetate (sodium salt of (2R)-5-(carboxymethoxy)-2-{[N,N-di(4-fluorophenyl)carbamoyloxy]methyl}-2-hydroxy-1,2,3,4-tetrahydronaphthalene) (111 mg) as white solid.

Provenance & Evidence