HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Ethynyl-4-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (4-Fluorophenylethynyl)trimethylsilane | HCID 5102724 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Ethynyl-4-fluorobenzene | HCID 522627 | — |
Reaction Steps
A 12-Liter 3-neck round-bottom flask equipped with a nitrogen inlet, an overhead mechanical stirrer, was charged with 6 Liters of methanol, the 1-fluoro-4-(trimethylsilyl)ethynylbenzene (1432 g) prepared above, and 98 g of anhydrous potassium carbonate. Stirring was continued until no starting material was detected by gas chromatographic analysis (about 1 hour).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06303733B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-3f98b9fbbb564d67b33b49684744d9ce |
| Source note | uspto-grants-2001_10 |