Potassium Carbonate → 1-Ethynyl-4-fluorobenzene

HRID 380710Notes

Reaction equation

HRID 380710 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][Si](C)(C)C)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)#[CH:9]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 5102724(4-Fluorophenylethynyl)trimethylsilane

Product 1

HCID 5226271-Ethynyl-4-fluorobenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 12-Liter 3-neck round-bottom flask equipped with a nitrogen inlet, an overhead mechanical stirrer, was charged with 6 Liters of methanol, the 1-fluoro-4-(trimethylsilyl)ethynylbenzene (1432 g) prepared above, and 98 g of anhydrous potassium carbonate. Stirring was continued until no starting material was detected by gas chromatographic analysis (about 1 hour).

Workup

  1. customA 12-Liter 3-neck round-bottom flask equipped with a nitrogen inlet, an overhead mechanical stirrer
  2. customwas detected by gas chromatographic analysis (about 1 hour)

Sources & evidence

ORD record
ord-3f98b9fbbb564d67b33b49684744d9ce
Source dataset
uspto-grants-2001_10
Patent number
US06303733B1

Reaction notes

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