反应详情

温度

100 °C

A mixture of 6.0 g (16.5 mMol) N-tert.-butyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide and 12 ml (185 mMol) methanesulfonic acid was stirred at 100° C. for 5 hours, then poured on ice. The aqueous phase was extracted with tert.-butyl-methylether, brought to pH=10 with NaOH aq. 28% and extracted further with tert.-butyl-methylether. The second organic extracts were dried (Na2SO4) and concentrated to yield 4.75 g (96%) 6-morpholin-4-yl-4-o-tolyl-nicotinamide as a light beige crystalline foam.

1. additionpoured on ice
2. extractionThe aqueous phase was extracted with tert.-butyl-methylether
3. extractionextracted further with tert.-butyl-methylether
4. dry with materialThe second organic extracts were dried (Na2SO4)
5. concentrationconcentrated