Potassium Carbonate → HCID 22568978, compound

HRID 381087Notes

Reaction equation

HRID 381087 reaction equation
COC(=O)CC1C=CC([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3([O:22][CH2:23][C:24]4C=CC=CC=4)[CH2:21][CH2:20]3)=[C:15]([CH3:30])[CH:14]=2)=CC=1.[C:32](=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([O:22][CH:23]([CH3:24])[CH3:32])[CH2:20][CH2:21]2)=[C:15]([CH3:30])[CH:14]=1)#[CH:11]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86585924Methyl{4-[4-(1-benzyloxycyclopropyl)-3-methyl-phenylethynyl]-phenyl}-acetate2×

Product 1

HCID 22568978HCID 22568978, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-trimethylsilane (Intermediate 80, 250.0 mg, 0.87 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (180 mg, 98%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-790917f9d6d242a197f703c608fea391
Source dataset
uspto-grants-2001_10
Patent number
US06303785B1

Reaction notes

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