Potassium Carbonate → 4-Ethynyl-1-(1-isopropoxycyclopropyl)-2-ethyl-benzene

HRID 381099Notes

Reaction equation

HRID 381099 reaction equation
[CH:1]([O:4][C:5]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[C:15][Si](C)(C)C)=[CH:10][C:9]=2[CH2:20][CH3:21])[CH2:7][CH2:6]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2([O:4][CH:1]([CH3:2])[CH3:3])[CH2:6][CH2:7]2)=[C:9]([CH2:20][CH3:21])[CH:10]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568952HCID 22568952, compound2×

Product 1

HCID 225688574-Ethynyl-1-(1-isopropoxycyclopropyl)-2-ethyl-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-isopropoxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane (Intermediate 94, 330.0 mg, 1.10 mmols) in methanol (10 mL) was treated with potassium carbonate (150.0 mg, 1.10 mmol) and stirred overnight at ambient temperature. The crude alkyne (238 mg, 95%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-2ccf6b5461c341f0a558a117b53a9ae3
Source dataset
uspto-grants-2001_10
Patent number
US06303785B1

Reaction notes

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