t-Butyl 3-methoxy-4-o-tolylureidophenylacetate → 3-Methoxy-4-o-tolylureidophenylacetic acid

HRID 381253Notes

Reaction equation

HRID 381253 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[CH:6]=[CH:7][C:8]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:11]>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:21]([OH:23])=[O:22])[CH:6]=[CH:7][C:8]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:11]

Participants

3

Reactant 1

HCID 69645017t-Butyl 3-methoxy-4-o-tolylureidophenylacetate

Product 1

HCID 114498403-Methoxy-4-o-tolylureidophenylacetic acidYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of t-butyl 3-methoxy-4-o-tolylureidophenylacetate (0.016 g, 0.043 mmol) in trifluoroacetic acid (1.0 mL) was stirred for 1 h. The reaction was concentrated and the residue coevaporated with methylene chloride (2×) then ether to afford 3-methoxy-4-o-tolylureidophenylacetic acid (0.0135 g, 100%) as a white residue.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-2e9aebfce6e34a6c8a11410be9a8e6e7
Source dataset
uspto-grants-2001_10
Patent number
US06306840B1

Reaction notes

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