HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 381286Generated: November 1, 2026
Hydrochloric Acid → 7-Oxo-5-trifluoromethyl-7h-thieno[3,2-b]pyran-3-carboxylic acid
https://huagongshe.com/reaction/381286
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 18399624 | HCID 18399624 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-Oxo-5-trifluoromethyl-7h-thieno[3,2-b]pyran-3-carboxylic acid | HCID 18399620 | 69.2% |
Reaction Steps
A mixture of 0.70 g of Compound 4A, 5.6 mL of dioxane and 8.4 mL of 9N hydrochloric acid was stirred at reflux for 75 minutes. After cooling to 20-25° C., the precipitated solid was filtered, washed with dioxane/water 1:1.5 and water to afford 0.46 g of the title compound as a grey solid melting at 249-251° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06306861B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-192b3aec450f43f183f3632dbf066944 |
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| Source note | uspto-grants-2001_10 |
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