Hydrochloric Acid → HCID 18399620, compound

HRID 381286Notes

Reaction equation

HRID 381286 reaction equation
[O:1]=[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[O:5][C:4]2[C:12]([C:15]([O:17]C)=[O:16])=[CH:13][S:14][C:3]1=2.Cl>O1CCOCC1>[O:1]=[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:9])[F:10])[O:5][C:4]2[C:12]([C:15]([OH:17])=[O:16])=[CH:13][S:14][C:3]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18399624HCID 18399624, compound

Product 1

HCID 18399620HCID 18399620, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
22.5 °C

Procedure

A mixture of 0.70 g of Compound 4A, 5.6 mL of dioxane and 8.4 mL of 9N hydrochloric acid was stirred at reflux for 75 minutes. After cooling to 20-25° C., the precipitated solid was filtered, washed with dioxane/water 1:1.5 and water to afford 0.46 g of the title compound as a grey solid melting at 249-251° C.

Workup

  1. temperatureat reflux for 75 minutes
  2. filtrationthe precipitated solid was filtered
  3. washwashed with dioxane/water 1:1.5 and water

Sources & evidence

ORD record
ord-192b3aec450f43f183f3632dbf066944
Source dataset
uspto-grants-2001_10
Patent number
US06306861B1

Reaction notes

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