HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Methyl 2-(1,3-benzodioxol-5-yl)-2-bromoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Methyl 2-(benzo[d][1,3]dioxol-5-yl)-2-hydroxyacetate | HCID 273389 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-(1,3-benzodioxol-5-yl)-2-bromoacetate | HCID 11821769 | — |
Reaction Steps
Hydrobromic acid (20 ml of 62%w/v solution in water) was added to methyl 2-(1,3-benzodioxol-5-yl)-2-hydroxyacetate (from step (b), 11 g, 52 mmol) in toluene (200 ml). After stirring for 3 hours the aqueous layer was removed and the organic layer was evaporated in vacuo. The residue was flash chromatographed, eluting with dichloromethane, and then crystallised with diisopropylether and hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306852B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-79592c0b822548a281dd4b48267eafd5 |
| Source note | uspto-grants-2001_10 |