反应详情

Hydrobromic acid (20 ml of 62%w/v solution in water) was added to methyl 2-(1,3-benzodioxol-5-yl)-2-hydroxyacetate (from step (b), 11 g, 52 mmol) in toluene (200 ml). After stirring for 3 hours the aqueous layer was removed and the organic layer was evaporated in vacuo. The residue was flash chromatographed, eluting with dichloromethane, and then crystallised with diisopropylether and hexane.

1. customwas removed
2. customthe organic layer was evaporated in vacuo
3. customchromatographed
4. washeluting with dichloromethane
5. customcrystallised with diisopropylether and hexane