Ethanolamine → HCID 499733, compound

HRID 381360Notes

Reaction equation

HRID 381360 reaction equation
CO[C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH2:25][CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[N:6][CH:5]=1.[CH2:28]([CH2:30][NH2:31])[OH:29]>>[CH2:25]([NH:24][C:23]1[C:18]([N:15]2[CH2:16][CH2:17][N:12]([C:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3](=[O:27])[NH:31][CH2:30][CH2:28][OH:29])=[CH:5][N:6]=3)=[O:11])[CH2:13][CH2:14]2)=[N:19][CH:20]=[CH:21][CH:22]=1)[CH3:26]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 702122536-[1-[3-(Ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester

Product 1

HCID 499733HCID 499733, compoundYield 73%

Procedure

By the same procedure as described in the example 2, synthesis was carried out starting with 6-[1-[3-(ethylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester and using ethanolamine. And then, the product was recrystallized with ethanol and hexane to give a desired compound.

Workup

  1. customBy the same procedure as described in the example 2, synthesis
  2. customAnd then, the product was recrystallized with ethanol and hexane

Sources & evidence

ORD record
ord-f99fb160fcfb4eb28108b763c8461ed3
Source dataset
uspto-grants-2001_10
Patent number
US06306860B1

Reaction notes

Loading…