Isobutylamine → HCID 18362843, compound

HRID 381368Notes

Reaction equation

HRID 381368 reaction equation
[CH3:1][CH:2]([CH3:30])[CH2:3][NH:4][C:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[C:26]([N+:27]([O-])=O)=[CH:25][CH:24]=[CH:23][N:22]=3)[CH2:17][CH2:16]2)=[O:14])=[N:11][CH:12]=1)=[O:6].C(N)C(C)C>>[NH2:27][C:26]1[C:21]([N:18]2[CH2:17][CH2:16][N:15]([C:13]([C:10]3[CH:9]=[CH:8][C:7]([C:5](=[O:6])[NH:4][CH2:3][CH:2]([CH3:1])[CH3:30])=[CH:12][N:11]=3)=[O:14])[CH2:20][CH2:19]2)=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 18362798HCID 18362798, compound

Product 1

HCID 18362843HCID 18362843, compoundYield 72%

Procedure

By the same procedure as described in the step (2) of example 27, the synthesis was carried out starting with 5-[N-(2-methylpropyl)carbamoyl]-2-[1-(3-nitro-2-pyridyl)piperazin-4-yl-carbonyl]pyridine, so prepared by Step (1) and using isobutylamine. And then, the product was recrystallized with ethanol and ether to give a desired compound.

Workup

  1. customso prepared by Step (1)
  2. customAnd then, the product was recrystallized with ethanol and ether

Sources & evidence

ORD record
ord-3175f943751f4db1b5ea6e858cbde720
Source dataset
uspto-grants-2001_10
Patent number
US06306860B1

Reaction notes

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