HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 6-[4-[3-(isopropylamino)-2-pyridyl]piperazine-1-carbonyl]-N-(2-methoxyethyl)pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 6-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester | HCID 10937848 | — |
| Product | 6-[4-[3-(isopropylamino)-2-pyridyl]piperazine-1-carbonyl]-N-(2-methoxyethyl)pyridine-3-carboxamide | HCID 499747 | 73% |
Reaction Steps
By the same procedure as described in the example 25, the synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester and using 2-methoxyethylamine. And then, the product was recrystallized with methylene chloride and hexane to give a desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306860B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-92981ba50f004223869a98c6953b6324 |
| Source note | uspto-grants-2001_10 |