2-Methoxyethylamine → 6-[4-[3-(isopropylamino)-2-pyridyl]piperazine-1-carbonyl]-N-(2-methoxyethyl)pyridine-3-carboxamide
Reaction equation
CO[C:3](=[O:28])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([NH:24][CH:25]([CH3:27])[CH3:26])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[N:6][CH:5]=1.[CH3:29][O:30][CH2:31][CH2:32][NH2:33]>>[CH:25]([NH:24][C:23]1[C:18]([N:15]2[CH2:14][CH2:13][N:12]([C:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3](=[O:28])[NH:33][CH2:32][CH2:31][O:30][CH3:29])=[CH:5][N:6]=3)=[O:11])[CH2:17][CH2:16]2)=[N:19][CH:20]=[CH:21][CH:22]=1)([CH3:27])[CH3:26]Participants
3
Procedure
By the same procedure as described in the example 25, the synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid methyl ester and using 2-methoxyethylamine. And then, the product was recrystallized with methylene chloride and hexane to give a desired compound.
Workup
- customAnd then, the product was recrystallized with methylene chloride and hexane
Sources & evidence
- ORD record
- ord-92981ba50f004223869a98c6953b6324
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06306860B1
Reaction notes
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