Aminoacetaldehyde dimethyl acetal → HCID 499749, compound

HRID 381378Notes

Reaction equation

HRID 381378 reaction equation
[CH:1]([NH:4][C:5]1[C:6]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([CH3:3])[CH3:2].[CH3:28][O:29][CH:30]([O:33][CH3:34])[CH2:31][NH2:32]>>[CH3:28][O:29][CH:30]([O:33][CH3:34])[CH2:31][NH:32][C:23]([C:22]1[CH:26]=[CH:27][C:19]([C:17]([N:14]2[CH2:15][CH2:16][N:11]([C:6]3[C:5]([NH:4][CH:1]([CH3:2])[CH3:3])=[CH:10][CH:9]=[CH:8][N:7]=3)[CH2:12][CH2:13]2)=[O:18])=[N:20][CH:21]=1)=[O:24]

Participants

3

Reactant 2

HCID 89728Aminoacetaldehyde dimethyl acetalHCID 183628186-[1-[3-(Isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid

Product 1

HCID 499749HCID 499749, compoundYield 78%

Procedure

By the same procedure as described in the example 24, the synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using 2,2-dimethoxyethylamine. And then, the product was crystallized with ethanol and hexane to give a desired compound.

Workup

  1. customAnd then, the product was crystallized with ethanol and hexane

Sources & evidence

ORD record
ord-504df727d0c549dc91b8608c69d40adf
Source dataset
uspto-grants-2001_10
Patent number
US06306860B1

Reaction notes

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