HRID381413

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H]1O[C@@]1(Cn1cncn1)c1ccc(F)cc1F

HCID10131191

未命名化合物

结构：CC(=O)S[C@H]1CC[C@H](/C=C/C=C/c2ccc(C(F)(F)F)cc2)CC1

HCID178477147

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](S[C@H]1CC[C@H](/C=C/C=C/c2ccc(C(F)(F)F)cc2)CC1)[C@](O)(Cn1cncn1)c1ccc(F)cc1F

HCID178462383

未命名化合物

收率 59%

PROCEDURE

实验过程

Reaction was carried out in the same manner as in Example 1 using (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane and trans-1-(acetylthio)-4-[(1E,3E)-4-[4-(trifluoromethyl)phenyl]-1,3-butadien-1-yl]cyclohexane as described in Reference example 43 to obtain the title compound having a melting point of 74 to 76° C. in a yield of 59%.

WORKUP

后处理

customReaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d8584ff49d4d4d6b841f5b7cc28cbb73
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06306880B1
来源说明: uspto-grants-2001_10

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@@:9]1([CH2:13][N:14]2[CH:18]=[N:17][CH:16]=[N:15]2)[C@H:11]([CH3:12])[O:10]1.C([S:22][C@H:23]1[CH2:28][CH2:27][C@H:26](/[CH:29]=[CH:30]/[CH:31]=[CH:32]/[C:33]2[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:41])[F:40])=[CH:35][CH:34]=2)[CH2:25][CH2:24]1)(=O)C>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:10])([C@H:11]([S:22][C@H:23]1[CH2:28][CH2:27][C@H:26](/[CH:29]=[CH:30]/[CH:31]=[CH:32]/[C:33]2[CH:34]=[CH:35][C:36]([C:39]([F:40])([F:41])[F:42])=[CH:37][CH:38]=2)[CH2:25][CH2:24]1)[CH3:12])[CH2:13][N:14]1[CH:18]=[N:17][CH:16]=[N:15]1