Hydrochloric Acid → HCID 69692374, compound

HRID 381525Notes

Reaction equation

HRID 381525 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]([C:8]1[O:12][N:11]=[C:10]([CH:13]([NH:18]C(OC(C)(C)C)=O)[CH2:14][CH:15]([CH3:17])[CH3:16])[CH:9]=1)=[O:7])[CH3:2].[ClH:27]>O1CCOCC1>[ClH:27].[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]([C:8]1[O:12][N:11]=[C:10]([CH:13]([NH2:18])[CH2:14][CH:15]([CH3:16])[CH3:17])[CH:9]=1)=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18682354HCID 18682354, compound

Product 1

HCID 69692374HCID 69692374, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-[3-(1-tert-butoxycarbonylamino-3-methyl-butyl)-isoxazol-5-yl]-3-oxo-propionic acid ethyl ester (1.4 g, 3.9 mmol) in 4M HCl in dioxane (5 ml) was stirred at room temperature. After 3 h the mixture was concentrated under reduced pressure to give the title compound as a pale yellow solid. MS [M+1]+ 269.0.

Workup

  1. concentrationAfter 3 h the mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-356a7f88114d43bb8e4348596113f068
Source dataset
uspto-grants-2001_10
Patent number
US06306887B1

Reaction notes

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