1,1'-Carbonyldiimidazole → HCID 18682354, compound

HRID 381526Notes

Reaction equation

HRID 381526 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:14]1[CH:18]=[C:17]([C:19]([OH:21])=O)[O:16][N:15]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O.[C:34]([O:40][CH2:41][CH3:42])(=[O:39])[CH2:35]C([O-])=O>>[CH2:41]([O:40][C:34](=[O:39])[CH2:35][C:19]([C:17]1[O:16][N:15]=[C:14]([CH:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:10][CH:11]([CH3:12])[CH3:13])[CH:18]=1)=[O:21])[CH3:42]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 3595298Propanedioic acid, monoethyl esterHCID 183139375-Isoxazolecarboxylic acid, 3-[1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methylbutyl]-

Product 1

HCID 18682354HCID 18682354, compound

Procedure

The title compound was prepared from 3-(1-tert-butoxycarbonylamino-3-methyl-butyl)-isoxazole-5-carboxylic acid by treatment with carbonyldiimidazole followed by the magnesium salt of mono-ethyl malonate as described in Angew. Chem. Int Ed. Eng., 18 (1979), p. 72.

Sources & evidence

ORD record
ord-ef24c017750f4dd588627d29f9f9c329
Source dataset
uspto-grants-2001_10
Patent number
US06306887B1

Reaction notes

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